Document 0329
 DOCN  M9460329
 TI    Introduction to the study of adult T-cell leukemia and HTLV-I
       sero-positivity in Romania.
 DT    9404
 AU    Motoiu IR; Pecek MM; Dumitrescu A; Colita A; Necula A; Moldoveanu E;
       Colita D; Clinic of Hematology, Fundeni Hospital, Bucharest, Romania.
 SO    Rom J Intern Med. 1993 Jul-Sep;31(3):199-205. Unique Identifier :
       AIDSLINE MED/94177131
 AB    The study presents 6 cases of leukemia/lymphoma (with mature T-cells)
       corresponding to the diagnostic criteria of adult T-cell leukemia (ATL):
       adult age onset of leukemia/lymphoma, organomegaly but normal
       mediastinum, leukemic cells with typical morphology and phenotype
       hypercalcemia. The evolution of disease was severe of subacute with
       resistance or partial response to therapy. The virologic assays were
       positive according to the ELISA test in four cases of which two
       presented, according to the Western blot assay, HTLV-I infection. The
       epidemic aspect of this infection is discussed as well as the
       possibility of contamination and the geographic spread of the places of
       origin of the patients. Emphasis is laid on the young age (22-26 years)
       of three of the patients infected, as a peculiar feature of the disease
       in Romania.
 DE    Adult  Blotting, Western  Enzyme-Linked Immunosorbent Assay  Female
       Human  HTLV-I Antibodies/*BLOOD  HTLV-I
       Infections/DIAGNOSIS/EPIDEMIOLOGY  HTLV-II Antibodies/BLOOD  Leukemia,
       T-Cell/*DIAGNOSIS/EPIDEMIOLOGY  Male  Middle Age  Phenotype
       Romania/EPIDEMIOLOGY  Seroepidemiologic Methods  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).