Document 0353
 DOCN  M9460353
 TI    The lack of correlation between the positivity of anti-platelet
       antibodies and the presence of thrombocytopenia in course of HIV
       infection.
 DT    9404
 AU    Riccio A; Natale D; Fratellanza G; Infranzi E; Farinaro C; Pronesti G;
       Casiere D; Tullio Cataldo P; Chirianni A; Bonadies G; Cattedra di
       Metodologia Clinica, Facolta di Medicina,; Universita Federico II di
       Napoli.
 SO    Boll Soc Ital Biol Sper. 1993 Mar;69(3):203-8. Unique Identifier :
       AIDSLINE MED/94176112
 AB    The presence of anti-platelet autoantibodies has been reported in many
       cases of HIV infection, but there is no accordance about their
       pathogenic role in the onset of thrombocytopenia in the patients
       studied. In the present study surface anti-platelet antibodies (PAIgG)
       and serum anti-platelet antibodies (sPAIgG) were assayed in a group of
       135 HIV-infected patients (109 men, 26 women), in different clinical
       stages by using an immunofluorescence test (PSIFT). In order to
       investigate the possible correlation of the positivity of these
       autoantibodies and the onset of thrombocytopenia, some of these patients
       were controlled in a follow-up study, with two successful controls: 10
       months (II control: 89 patients) and 20 months (III control: 59
       patients) after the first time. In the I control PAIgG were positive in
       68 subjects (50.4%) and sPAIgG in 34 (25.2%); both PAIgG and sPAIgG were
       present in 23 patients (17%). 56 patients did not present anti-plt
       antibodies (41.5%). No significantly different distribution of these
       autoantibodies in each stage of disease was observed. The mean value of
       platelet count resulted in the normal range both in the anti-plt
       antibody positive and in the anti-plt antibody negative patients, but
       the value found in the anti-plt antibody positive patients was
       significantly lower than the one found in the anti-plt antibody negative
       group (p < 0.01). This difference was more marked between the group with
       PAIgG and anti-plt antibody negative patients than between the group
       with sPAIgG and the anti-plt antibody negative patients (p <
       0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adolescence  Adult  Antibody Specificity
       Autoantibodies/BIOSYNTHESIS/*BLOOD/IMMUNOLOGY  Blood
       Platelets/*IMMUNOLOGY  Child  Female  Follow-Up Studies  Human  HIV
       Infections/BLOOD/*COMPLICATIONS/IMMUNOLOGY  Male  Middle Age
       Thrombocytopenia/*COMPLICATIONS/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).