Document 0360 DOCN M9460360 TI Inhibition of human immunodeficiency virus type 1 replication by human interferons alpha, beta and gamma. DT 9404 AU Yamamoto JK; Kruzel ML; Louie H; Georgiades JA; Department of Medicine, School of Veterinary Medicine, University; of California, Davis 95616. SO Arch Immunol Ther Exp (Warsz). 1993;41(3-4):185-91. Unique Identifier : AIDSLINE MED/94175716 AB The effect of various preparations of human interferon (HuIFN) upon human immunodeficiency virus (HIV-1) replication in cell lines and primary cultures of peripheral blood lymphocytes (PBL) was investigated. Natural interferon alpha (nHuIFN-alpha) exhibited a much higher inhibitory effect upon HIV-1 replication than did recombinant HuIFN-alpha (rHuIFN-alpha). DE Cell Line Human HIV-1/*DRUG EFFECTS/PHYSIOLOGY Interferon Type II/PHARMACOLOGY Interferon-alpha/PHARMACOLOGY Interferon-beta/PHARMACOLOGY Interferons/*PHARMACOLOGY Lymphocytes/MICROBIOLOGY Support, U.S. Gov't, P.H.S. Virus Replication/*DRUG EFFECTS JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).