Document 0385
 DOCN  M9460385
 TI    Detection of the pX gene of human T-lymphotropic virus type I in
       respiratory diseases with diffuse interstitial pulmonary shadows and
       lung cancer.
 DT    9404
 AU    Imajo K; Shinagawa K; Tada S; Tsubota T; Kimura I; Second Department of
       Internal Medicine, Okayama University; Medical School, Japan.
 SO    Acta Med Okayama. 1993 Dec;47(6):363-8. Unique Identifier : AIDSLINE
       MED/94175024
 AB    The presence of the HTLV-I gene in peripheral blood mononuclear cells
       was studied by polymerase chain reaction in 42 patients including 16
       with lung cancer, 12 with diffuse panbronchiolitis (DPB), 11 with
       idiopathic interstitial pneumonia (IIP), and 3 with pneumoconiosis and
       hematological malignancy. Sequences equal to a part of the pX gene were
       found in 44% of the lung cancer cases, 50% of the DPB cases, 55% of the
       IIP cases, and 100% of the cases of pneumoconiosis and leukemia. In the
       lung cancer cases, detection of the pX gene was frequently associated
       with the existence of diffuse interstitial pulmonary shadows. The pX
       gene was detected in 100% of patients with anti-HTLV-I antibody, 50% of
       patients with HTLV-I-related reaction and 14% of patients who tested
       seronegative. It may be inferred from the results that respiratory
       diseases that produce diffuse interstitial pulmonary shadows are closely
       associated with HTLV-I infection and that the HTLV-I-related reaction to
       the immunofluorescent test might reflect the latent infection state of
       HTLV-I.
 DE    Base Sequence  Female  *Genes, pX  Human  HTLV-I/*GENETICS  Leukemia,
       Myelocytic, Acute/GENETICS  Lung Diseases, Interstitial/GENETICS  Lung
       Neoplasms/*GENETICS  Male  Molecular Probes/GENETICS  Molecular Sequence
       Data  Myelodysplastic Syndromes/GENETICS  Pneumoconiosis/GENETICS
       Polymerase Chain Reaction  Respiration Disorders/*GENETICS  JOURNAL
       ARTICLE

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