Document 0387
 DOCN  M9460387
 TI    Fluconazole-resistant Cryptococcus neoformans var gattii in an AIDS
       patient.
 DT    9404
 AU    Peetermans W; Bobbaers H; Verhaegen J; Vandepitte J; Department of
       Internal Medicine, Universitaire Ziekenhuizen, K.U.; Leuven, Belgium.
 SO    Acta Clin Belg. 1993;48(6):405-9. Unique Identifier : AIDSLINE
       MED/94174929
 AB    We describe a case of meningitis due to Cryptococcus neoformans var
       gattii in an AIDS patient. The reasons for the observed predominance of
       C. neoformans var neoformans infections in AIDS patients living in areas
       endemic for the gattii variety are not understood thus far. Treatment
       with fluconazole resulted in poor clinical and mycological response. In
       vitro sensitivity testing of the fungus revealed high minimal inhibitory
       concentrations, suggesting fluconazole resistance. Treatment with
       amphotericin B was successful.
 DE    Adult  AIDS-Related Opportunistic Infections/*MICROBIOLOGY  Case Report
       Cryptococcus neoformans/CLASSIFICATION/DRUG EFFECTS/*ISOLATION &  PURIF
       Drug Resistance, Microbial  Female
       Fluconazole/PHARMACOLOGY/*THERAPEUTIC USE  Human  Meningitis,
       Cryptococcal/DRUG THERAPY/*MICROBIOLOGY  JOURNAL ARTICLE

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