Document 0392
 DOCN  M9460392
 TI    Cytotoxic T lymphocytes directed against MAIDS-associated tumors and
       cells from mice infected by the LP-BM5 MAIDS defective retrovirus.
 DT    9404
 AU    Green WR; Crassi KM; Schwarz DA; Green KA; Department of Microbiology,
       Dartmouth Medical School, Lebanon,; New Hampshire 03756.
 SO    Virology. 1994 Apr;200(1):292-6. Unique Identifier : AIDSLINE
       MED/94174730
 AB    The LP-BM5 retrovirus, a complex containing ecotropic helper,
       recombinant MCF, and defective retroviruses, causes an
       immunodeficiency-termed mouse AIDS (MAIDS). Many disease features of
       MAIDS resemble those of AIDS, including terminal B cell lymphomas.
       Previously we generated from MAIDS-susceptible C57BL/6 mice cytolytic T
       lymphocytes (CTL) specific for MAIDS-associated B cell lymphomas. Data
       of the present study (1) exclude MCF and establish a role for defective
       virus in generating C57BL/6 CTL to MAIDS-associated tumors by
       experiments involving in vitro stimulation with cells from LP-BM5,
       ecotropic, or ecotropic-rescued defective virus-infected mice and (2)
       confirm that such CTL are specific for tumors of MAIDS origin. Several
       approaches testing for direct involvement of defective virus or its
       gag-encoded polyprotein, however, did not provide evidence that MAIDS
       tumor-specific CTL were directed to structural virion proteins,
       suggesting the possibility that such CTL are specific for nonvirion
       antigens whose expression depends on the action of the defective genome
       in the MAIDS disease process.
 DE    Animal  *Defective Viruses  Gene Products, gag/IMMUNOLOGY  *Leukemia
       Viruses, Murine  Lymphoma, B-Cell/COMPLICATIONS/*IMMUNOLOGY  Male  Mice
       Mice, Inbred C57BL  Murine Acquired Immunodeficiency
       Syndrome/COMPLICATIONS/  *IMMUNOLOGY  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes, Cytotoxic/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).