Document 0394
 DOCN  M9460394
 TI    The rev gene of visna virus is required for productive infection.
 DT    9404
 AU    Toohey KL; Haase AT; Department of Microbiology, University of
       Minnesota, Minneapolis; 55455.
 SO    Virology. 1994 Apr;200(1):276-80. Unique Identifier : AIDSLINE
       MED/94174726
 AB    To assess the role of the animal lentivirus rev regulatory gene product
       in the life cycle of visna virus, we introduced mutations into the
       functional fourth exon of the rev gene of visna virus. Cultured cells
       transfected with a full-length clone of visna DNA produce infectious
       virus but visna DNA with mutations in rev does not. The documented
       requirement for a functional rev gene in productive infections
       establishes the essential role of this gene in the replication of an
       animal lentivirus.
 DE    Amino Acid Sequence  Base Sequence  Comparative Study  Cytopathogenic
       Effect, Viral  Exons/GENETICS  Genes, rev/*GENETICS  Genetic
       Complementation Test  In Situ Hybridization  Molecular Sequence Data
       Mutagenesis, Site-Directed  Point Mutation  Proviruses/*GROWTH &
       DEVELOPMENT/GENETICS  Reverse Transcriptase/ANALYSIS  RNA,
       Viral/ISOLATION & PURIF  Transfection  Virus Replication  Visna-Maedi
       Virus/*GROWTH & DEVELOPMENT/GENETICS  JOURNAL ARTICLE

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