Document 0395
 DOCN  M9460395
 TI    Cellular thymidine kinase activity is required for the inhibition of
       HIV-1 replication by AZT in lymphocytes.
 DT    9404
 AU    Lowy I; Caruso M; Goff SP; Klatzmann D; Department of Medicine, Columbia
       University, New York, New York; 10032.
 SO    Virology. 1994 Apr;200(1):271-5. Unique Identifier : AIDSLINE
       MED/94174725
 AB    In this report, we provide evidence that the cellular thymidine kinase
       activity is required for the inhibition of HIV replication by zidovudine
       (AZT) in lymphocytes. The HSV-1 thymidine kinase protein is not able to
       substitute for the cellular enzyme, in accord with in vitro data that
       AZT is poorly phosphorylated by the HSV-derived activity.
 DE    Drug Resistance, Microbial  HIV-1/*DRUG EFFECTS/GROWTH & DEVELOPMENT
       Lymphocytes/*ENZYMOLOGY/MICROBIOLOGY  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  Thymidine Kinase/*METABOLISM  Thymine
       Nucleotides/BIOSYNTHESIS  Virus Replication/DRUG EFFECTS
       Zidovudine/ANALOGS & DERIVATIVES/METABOLISM/*PHARMACOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).