Document 0402
 DOCN  M9460402
 TI    Heparin cofactor II deficiency in patients infected with the human
       immunodeficiency virus.
 DT    9404
 AU    Toulon P; Lamine M; Ledjev I; Guez T; Holleman ME; Sereni D; Sicard D;
       Laboratoire d'Hematologie, Hopital Cochin, Paris, France.
 SO    Thromb Haemost. 1993 Nov 15;70(5):730-5. Unique Identifier : AIDSLINE
       MED/94174502
 AB    In human plasma, heparin cofactor II (HCII) is a thrombin inhibitor,
       whose deficiency has been reported to be associated with recurrent
       thrombosis. The finding of two cases of low plasma HCII activity in two
       patients infected with the human immunodeficiency virus (HIV) led us to
       investigate this coagulation inhibitor in the plasma of a larger
       population of HIV-infected patients. The mean plasma HCII activity was
       significantly lower in 96 HIV-infected patients than in 96 age- and
       sex-matched healthy individuals (0.75 +/- 0.24 vs 0.99 +/- 0.17 U/ml, p
       < 0.0001). HCII antigen concentration was decreased to the same extent
       as the activity. The proportion of subjects with HCII deficiency was
       significantly higher in the HIV-infected group than in healthy
       individuals (38.5% vs 2.1%). In addition, HCII was significantly lower
       in AIDS patients than in other HIV-infected patients, classified
       according to the Centers for Disease Control (CDC) on the basis of an
       absolute number of circulating CD4+ lymphocytes below 200 x 10(6)/l. The
       link between HCII and immunodeficiency is further suggested by
       significant correlations between HCII activity and both the absolute
       number of CD4+ lymphocytes and the CD4+ to CD8+ lymphocyte ratio.
       Nevertheless, the mean HCII level was not different in the various
       groups of patients classified according to clinical criteria, except in
       CDC IVD patients in whom HCII levels were significantly lower. In
       addition, no correlation could be demonstrated between HCII and protein
       S activities, another coagulation inhibitor whose plasma level was also
       found to be decreased in HIV-infected patients.(ABSTRACT TRUNCATED AT
       250 WORDS)
 DE    Adult  Aged  CD4-CD8 Ratio  Female  Heparin Cofactor II/*DEFICIENCY
       Human  HIV Infections/*BLOOD/COMPLICATIONS  Leukocyte Count  Male
       Middle Age  Protein S/ANALYSIS  Support, Non-U.S. Gov't
       Thrombosis/COMPLICATIONS  JOURNAL ARTICLE

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