Document 0414
 DOCN  M9460414
 TI    [The sensitivity and specificity of the clinical, serological and
       tomographic diagnosis of Toxoplasma gondii encephalitis in the acquired
       immunodeficiency syndrome (AIDS)]
 DT    9404
 AU    Wainstein MV; Wolffenbuttel L; Lopes DK; Gonzalez HE; Golbspan L;
       Ferreira L; Sprinz E; Kronfeld M; Edelweiss MI; Unidade de Doencas
       Infecciosas, Hospital de Clinicas de Porto; Alegre, HCPA, RS, Brasil.
 SO    Rev Soc Bras Med Trop. 1993 Apr-Jun;26(2):71-5. Unique Identifier :
       AIDSLINE MED/94174110
 AB    Toxoplasmic encephalitis (TE) is among the most common neurologic
       affections and it is the most prevalent cause of intracerebral mass
       lesions in AIDS patients. All patients with AIDS hospitalized at the
       Hospital de Clinicas de Porto Alegre between May/85 and December/91 (516
       cases) had their files revised to determinate TE prevalence, serology,
       sensitivity and specificity of the computed tomography (CT) brain scan,
       clinical findings and serology to make its diagnosis. The prevalence on
       CT was 13% (presumptive diagnosis). Blood serology and cerebrospinal
       (CSF) serology to toxoplasma were positive respectively in 65% and 49%.
       Autopsies of 125 patients were also revised with a prevalence of 22%
       (definite diagnosis). CT scan had 65% of sensitivity and 82% of
       specificity. Sensitivity and specificity of serology on blood was
       respectively 95% and 30%, while the cerebrospinal fluid (CSF) serology
       had 77% of sensitivity and 56% of specificity. The following clinical
       findings were considered: fever (sensitivity = 92%; specificity = 56%),
       neurological focal signs (sensitivity = 59%; specificity = 82%) and
       headache (sensitivity = 41%; specificity = 69%). We conclude that, based
       on the high serology sensitivity and high CT scan specificity, they
       constitute an useful approach to make TE diagnosis.
 DE    Animal  Antibodies, Protozoan/*BLOOD  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/EPIDEMIOLOGY/  PATHOLOGY  Brain/PATHOLOGY
       Brazil/EPIDEMIOLOGY  Encephalitis/*DIAGNOSIS/EPIDEMIOLOGY/PATHOLOGY
       English Abstract  Female  Fluorescent Antibody Technique  Human  *HIV-1
       Male  Prevalence  Sensitivity and Specificity  *Tomography, X-Ray
       Computed  Toxoplasma/*IMMUNOLOGY  Toxoplasmosis,
       Cerebral/*DIAGNOSIS/EPIDEMIOLOGY/PATHOLOGY  JOURNAL ARTICLE

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