Document 0415
 DOCN  M9460415
 TI    [The neuropathology of the acquired immunodeficiency syndrome (AIDS)]
 DT    9404
 AU    Chimelli L; Rosemberg S; Departamento de Patologia, Faculdade de
       Medicina de Ribeirao; Preto, Universidade de Sao Paulo.
 SO    Rev Soc Bras Med Trop. 1993 Apr-Jun;26(2):113-9. Unique Identifier :
       AIDSLINE MED/94174107
 AB    The nervous system is frequently involved in patients with AIDS. The
       lesions can be due to the human immunodeficiency virus (HIV), to
       opportunistic agents, to the development of tumours, and to occasional
       nonspecific factors, such as circulatory, metabolic and degenerative
       changes. The changes directly related to the presence of the HIV include
       the HIV encephalitis and leucoencephalopathy, the diffuse polydystrophy
       and the vacuolar myelopathy. The pathogenesis of these lesions is not
       yet completely clear. Macrophages are the main cells infected by the
       HIV, and it seems that the cytotoxic effects on the nervous tissue are
       indirect, may be due to the release of substances by infected
       macrophages. Among the opportunistic infections, the most frequent is
       toxoplasmosis followed by cryptococcosis and cytomegalovirus infection,
       with some differences in series from various countries. Many other
       agents have been observed in the brain of patients with AIDS. B-cell
       lymphoma is the most frequent tumour found in the brain and it is not
       uncommon the association of infections and/or tumours.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  AIDS Dementia
       Complex/ETIOLOGY  AIDS-Related Opportunistic Infections/ETIOLOGY  Brain
       Neoplasms/ETIOLOGY  English Abstract  Human  *HIV-1/PATHOGENICITY
       Lymphoma, AIDS-Related/ETIOLOGY  Nervous System Diseases/*ETIOLOGY
       Sarcoma, Kaposi's/ETIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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