Document 0426
 DOCN  M9460426
 TI    Sensitivity of the Papanicolaou smear in human immunodeficiency
       virus-infected women.
 DT    9404
 AU    Korn AP; Autry M; DeRemer PA; Tan W; Department of Obstetrics,
       Gynecology, and Reproductive Sciences,; University of California, San
       Francisco.
 SO    Obstet Gynecol. 1994 Mar;83(3):401-4. Unique Identifier : AIDSLINE
       MED/94173529
 AB    OBJECTIVE: To determine the sensitivity of the Papanicolaou smear in
       human immunodeficiency virus (HIV)-infected women. METHODS: Fifty-two
       HIV-seropositive women underwent colposcopy and had cytologic and
       histologic specimens obtained. Eighty-five consecutive women seen in our
       colposcopy clinic who stated that they were HIV-seronegative formed the
       comparison group. Demographic features of the groups and cytology and
       histology findings were compared. RESULTS: In HIV-infected patients, the
       prevalence of cervical dysplasia was 50%. An additional 15% had vulvar
       lesions alone. The sensitivity of cytologic smears for cervical
       dysplasia was 63% and specificity was 84%. These findings were not
       significantly different from those of a control group of women
       undergoing colposcopy for standard indications (P > .05). Twelve of 38
       seropositive women for whom future appointments were scheduled were lost
       to follow-up. CONCLUSIONS: The sensitivity of the Papanicolaou test does
       not appear to be diminished in HIV-seropositive women. Screening
       colposcopy may be justified in view of the high prevalence of cervical
       and vulvar dysplasia, as well as the high noncompliance rate observed in
       this patient population.
 DE    Adult  Biopsy  Cervix Dysplasia/COMPLICATIONS/*PATHOLOGY  Female
       Follow-Up Studies  Human  HIV Seropositivity/*COMPLICATIONS  Predictive
       Value of Tests  Sensitivity and Specificity  Support, U.S. Gov't, P.H.S.
       *Vaginal Smears  Vulva/PATHOLOGY  JOURNAL ARTICLE

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