Document 0433
 DOCN  M9460433
 TI    [The development of a new experimental model of pneumocystosis]
 DT    9404
 AU    Lavdovskaia MV; Kovalenko FP; Lysenko AIa; Strelkova MV; Chernov IuV
 SO    Med Parazitol (Mosk). 1993 Oct-Dec;(5):26-34. Unique Identifier :
       AIDSLINE MED/94173218
 AB    The corticosteroid tricort-40 (triamcinolone acetonide) was found to
       induce the reactivation of endogenous pneumocystic injection caused by
       P. carinii in Wistar rats given 5-9 infections subcutaneously in median
       doses of 0.5-4.0 mg/kg at 6-22 days intervals each. Manifest P. carinii
       infection in the animals was characterized by early detection of its
       agent (starting from week 2 of immunosuppression), a progression of the
       infection and its transition to the generalized stage. The combined use
       of tricort-40 and infection of the animals with Leishmania infantum as
       an immunosuppressive cofactor ensured an increase in reproducibility of
       a manifest pneumocystosis model and its more rapid transition to the
       generalized stage. The experimental model of mixed infection of two
       AIDS-associated parasite infections--generalized pneumocystosis and
       visceral leishmaniasis--was first reproduced in inbred rats, which may
       be suitable for simultaneous screening of new antipneumocystic and
       antileishmanial drugs.
 DE    Animal  Delayed-Action Preparations  *Disease Models, Animal  English
       Abstract  Female  Immunosuppressive Agents/PHARMACOLOGY  Leishmania
       infantum/PATHOGENICITY  Male  Pneumocystis carinii/PATHOGENICITY
       Pneumocystis carinii Infections/*ETIOLOGY/IMMUNOLOGY/MICROBIOLOGY  Rats
       Rats, Wistar  Time Factors  Triamcinolone Acetonide/PHARMACOLOGY
       JOURNAL ARTICLE

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