Document 0440
 DOCN  M9460440
 TI    [Incidence and etiology of viremia in 2,619 patients]
 DT    9404
 AU    Caballero Requero E; Martinez Cuevas O; Cortes Borra A; Fernandez Perez
       F; Capdevila JA; Calico I; Servicio de Microbiologia y Parasitologia,
       Hospital General; Universitario Vall d'Hebron, Barcelona.
 SO    Med Clin (Barc). 1994 Feb 12;102(5):161-4. Unique Identifier : AIDSLINE
       MED/94173113
 AB    BACKGROUND: Virus investigation, specially cytomegalovirus (CMV), in
       blood has increased such that the capacity of hospitalary laboratories
       is threatened with collapse. The causal agents of viremia are analyzed
       being correlated with the clinical symptoms and underlying disease to
       establish the selection criteria of patients for virologic study.
       METHODS: Two thousand six hundred nineteen patients suspected of having
       viral infection, fundamentally by CMV were studied over 6 years by 4,394
       blood samples. Of these patients 1,646 were immunosuppressed, 824 were
       considered immunocompetent and this data was unknown in 149 patients.
       The leukocytes were separated using standardized techniques being seeded
       in cell cultures (human embryo lung fibroblasts). RESULTS: Three hundred
       forty-seven specimens corresponding to 242 patients were positive with
       isolation of the following pathogens: 327 strains of CMV, 4 enterovirus,
       2 adenovirus, 1 herpes simplex virus, 1 varicella-zoster, another 5
       unidentified cytopathic agents, 6 strains of toxoplasma and 1
       Cryptococcus. With regard to the base disease, 302 positive samples to
       CMV pertained to 204 immunosuppressed patients: 103 (13.6% positives
       among the cases studied) AIDS or AIDS-related complex, 54 (21.3%) kidney
       transplant patients, 31 (24.8%) liver transplant patients, 2 (1.5%) lung
       transplant patients, and 2 (1.5%) bone marrow transplant patients. A non
       CMV microorganism was isolated in 13 samples from 12 immunosuppressed
       patients. Only 24 (2.5% of those studied) immunocompetent or with
       unknown immunity status had viremia by CMV, being detected in 25
       samples. Non CMV cytopathic agents were isolated in another 7 samples
       from 6 patients. CONCLUSIONS: Analysis of blood cultures allows the
       isolation of cytomegalovirus and occasionally other unsuspected agents
       such as toxoplasma. This investigation is indicated in immunosuppressed
       patients but not in immunocompetent patients who present a febrile
       syndrome with no clinical suspicion of cytomegalovirus infection.
 DE    Adult  Child  Cytomegalovirus Infections/EPIDEMIOLOGY/*ETIOLOGY  English
       Abstract  Human  *Immunocompromised Host  Immunosuppression/*ADVERSE
       EFFECTS  Incidence  Viremia/EPIDEMIOLOGY/*ETIOLOGY/MICROBIOLOGY  JOURNAL
       ARTICLE

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