Document 0442
 DOCN  M9460442
 TI    T-cell receptor J beta I/J beta II locus rearrangements concurring with
       a complex chromosomal aberration in an HTLV-1 positive T-cell lymphoma.
 DT    9404
 AU    Macera MJ; DiPillo F; Szabo P; Ramirez R; Gogineni S; Verma RS;
       Department of Medicine, Long Island College Hospital, SUNY, New; York.
 SO    Leukemia. 1994 Mar;8(3):420-4. Unique Identifier : AIDSLINE MED/94173091
 AB    Human T-lymphotropic virus type I (HTLV-1) integration has been
       associated with the development of adult T-cell leukemia/lymphoma (ATL).
       Recently, a correlation between T-cell receptor (TCR) gene
       rearrangements and chromosomal aberrations has been implicated in this
       leukemia. We present a case of HTLV-1 infected adult T-cell lymphoma
       that initially presented with a normal karyotype and germline J beta I/J
       beta II loci. As the disease evolved to the aggressive stage, a complex
       chromosomal rearrangement with a duplication of chromosome 6p23-->pter
       translocated to a derivative chromosome 16, was identified by molecular
       cytogenetic techniques. The nature of this complex abnormality would
       have been difficult to determine if only conventional banding techniques
       were performed. Rearrangement involving one J beta allele was also
       detected at that time. After initiation of chemotherapy, no germline J
       beta loci were detected, suggesting a possible second rearrangement
       involving this locus that was homologous. Although no known immune
       response genes are located at the breakpoints involved in this
       abnormality, the chromosomal aberration concurred with the initial J
       beta rearrangement.
 DE    Adult  Antineoplastic Agents, Combined/THERAPEUTIC USE
       Bleomycins/ADMINISTRATION & DOSAGE  Case Report  *Chromosomes, Human,
       Pair 16  *Chromosomes, Human, Pair 6  *Chromosomes, Human, Pair 7
       Cyclophosphamide/ADMINISTRATION & DOSAGE  Dexamethasone/ADMINISTRATION &
       DOSAGE  Doxorubicin/ADMINISTRATION & DOSAGE  DNA, Neoplasm/ANALYSIS
       Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/*GENETICS  Human
       Karyotyping  Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/DRUG
       THERAPY/  *GENETICS  Male  Nucleic Acid Hybridization/METHODS
       *Translocation (Genetics)  Vincristine/ADMINISTRATION & DOSAGE  JOURNAL
       ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).