Document 0443
 DOCN  M9460443
 TI    [Recent advances in immunological diagnosis for tuberculosis]
 DT    9404
 AU    Morishita M; Magaki K; Katoh H; Ikeda I; Oguri T; Ohshika H; Suzuki M;
       Kawaguchi H; Torii Y; Ina Y; et al; Second Department of Internal
       Medicine, Aichi Medical University,; Japan.
 SO    Kekkaku. 1994 Feb;69(2):97-106. Unique Identifier : AIDSLINE
       MED/94172918
 AB    Recent advances in immunological diagnosis for tuberculosis including
       tuberculin Mantoux test and serodiagnosis were reviewed. New tuberculins
       (T1327, T1456) were reported to be more specific than the conventional
       one (RT23). Tuberculins from atypical mycobacteria (PPD-B, PPD-Y, PPD-F)
       were reported as a useful tool for the diagnosis of atypical
       mycobacteriosis. Optical density index method is a most appropriate
       method for a clinical use among several methods for the expression of
       antigen titer in serodiagnosis using ELISA. The duration of disease is
       important for understanding the results. IgM antibody rises in the early
       stage of the disease and comes down in 10 weeks after onset, while IgG
       antibody rises lately. Anti-cord factor antibody is a highly specific
       antibody for tuberculosis and may be a potent candidate for a clinical
       diagnostic tool. Anti-PPD-B antibody was elevated in atypical
       mycobacteriosis and pulmonary tuberculosis also. The ratio of anti-PPD-B
       antibody to anti-PPDs antibody was elevated in atypical mycobacteriosis
       while it was lowered in pulmonary tuberculosis. It may be helpful for
       suggesting the causative organism when the sputum smear is positive. The
       opposite results have been reported on the serodiagnosis in HIV
       infection. The usefulness of serodiagnosis for tuberculosis in HIV
       infected patients remained controversial.
 DE    Antibodies, Bacterial/ANALYSIS  English Abstract  Enzyme-Linked
       Immunosorbent Assay  Human  Sensitivity and Specificity  Serodiagnosis
       Tuberculin/IMMUNOLOGY  *Tuberculin Test  Tuberculosis/*DIAGNOSIS
       JOURNAL ARTICLE  REVIEW  REVIEW LITERATURE

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