Document 0447
 DOCN  M9460447
 TI    Lymphomatous meningitis in AIDS-related systemic non-Hodgkin's lymphoma:
       a report of eight cases.
 DT    9404
 AU    Enting RH; Esselink RA; Portegies P; Department of Internal Medicine,
       Academic Medical Centre,; Amsterdam, The Netherlands.
 SO    J Neurol Neurosurg Psychiatry. 1994 Feb;57(2):150-3. Unique Identifier :
       AIDSLINE MED/94172378
 AB    Meningeal involvement occurred in eight (22%) of 36 adult patients with
       AIDS-related systemic non-Hodgkin's lymphoma, seen over a 10-year
       period. Clinical symptoms consisted of cranial nerve palsies, radicular
       involvement, headache or diffuse encephalopathy. CSF examination
       established the diagnosis in all cases. Systemic disease had been
       diagnosed seven to 33 weeks before lymphomatous meningitis in six
       patients, whereas in the remaining two patients diagnoses of systemic
       and meningeal disease were made simultaneously. All patients had
       intermediate or high grade lymphomas and widespread disease. In contrast
       to non-AIDS related lymphomas, bone marrow involvement at initial
       staging cannot be used to select patients for prophylactic treatment, as
       seven of our eight patients had no initial bone marrow involvement. In
       this retrospective review, prognosis of lymphomatous meningitis was
       extremely poor, with a mean survival of only five weeks. Survival of
       patients with systemic lymphoma who eventually developed lymphomatous
       meningitis was 4.0 months compared with 7.2 months for those who did
       not. Lymphomatous meningitis appears to have the worst outcome of all
       AIDS-related neurological complications, regardless of treatment.
 DE    Adult  Diagnosis, Differential  Female  Human  Lymphoma,
       AIDS-Related/*COMPLICATIONS  Lymphoma,
       Non-Hodgkin's/*COMPLICATIONS/MICROBIOLOGY  Male  Meningitis,
       Aseptic/DIAGNOSIS/*ETIOLOGY/THERAPY  Middle Age  Retrospective Studies
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).