Document 0448
 DOCN  M9460448
 TI    Serial MRI of the brain in asymptomatic patients infected with HIV:
       results from the UCMSM/Medical Research Council neurology cohort.
 DT    9404
 AU    Manji H; Connolly S; McAllister R; Valentine AR; Kendall BE; Fell M;
       Durrance P; Thompson AJ; Newman S; Weller IV; et al; Department of
       Neurological Studies, University College and; Middlesex School of
       Medicine, London, UK.
 SO    J Neurol Neurosurg Psychiatry. 1994 Feb;57(2):144-9. Unique Identifier :
       AIDSLINE MED/94172377
 AB    Seventy-six homosexual or bisexual men underwent two cranial MRI studies
       at a mean interval of 13 months; 23 were HIV seronegative, 41
       seropositive but asymptomatic (Center for Disease Control (CDC) groups
       II/III), and 12 had AIDS related complex (ARC)/AIDS (CDC group IV).
       Agreement between two neuroradiologists was rated as very good for
       assessment of enlargement of ventricles and good for widening of
       cerebral sulci and the presence of focal lesions. For assessment of
       serial studies, the agreement was moderate. The prevalence of cerebral
       atrophy and focal white matter lesions was no higher in the asymptomatic
       patients (CDC group II/III) than in appropriate seronegative controls.
       Some patients with ARC/AIDS showed evidence of developing cerebral
       atrophy during the study period when serial scans were compared. The
       imaging evidence supports the other data obtained from this cohort,
       which suggest that no significant CNS involvement occurs in HIV
       infection before the development of ARC/AIDS.
 DE    Adult  Atrophy  Brain/*PATHOLOGY/RADIOGRAPHY  Human  HIV
       Seropositivity/*PATHOLOGY/RADIOGRAPHY  Magnetic Resonance
       Imaging/METHODS  Male  Support, Non-U.S. Gov't  JOURNAL ARTICLE

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