Document 0461
 DOCN  M9460461
 TI    Cognitive behavior in asymptomatic (CDC stage II and III)
       HIV--seropositive intravenous drug users (IVDUs).
 DT    9404
 AU    Del Pesce M; Franciolini B; Censori B; Bartolini M; Ancarani F; Petrelli
       E; Provinciali L; Istituto delle Malattie del Sistema Nervoso,
       Universita degli; Studi di Ancona.
 SO    Ital J Neurol Sci. 1993 Dec;14(9):619-25. Unique Identifier : AIDSLINE
       MED/94171534
 AB    To evaluate cognitive impairment in the early stages of HIV infection in
       intravenous drug users (IVDUs) we have studied 39 consecutive
       HIV-infected subjects (CDC stage II-III) whose only known risk factor
       for the infection was intravenous heroin addiction. The control group
       was represented by 30 seronegative IVDUs. All subjects were tested with
       an extensive neuropsychological battery assessing general intellectual
       abilities and single cognitive functions. The patients differed from
       controls only for tests of attention and visual-motor abilities: 20% of
       asymptomatic seronegative and PGL patients showed alterations in two or
       more cognitive tests, as opposed to 3% of controls (p < 0.001). Our
       findings suggest that cognitive deficits seem to be present in a
       substantial percentage of IVDUs with asymptomatic HIV infection.
       Cognitive damage at this stage seems to selectively involve attention
       and visual-motor abilities, sparing general intellectual performances.
 DE    Adult  *Cognition  Female  Human  HIV
       Seropositivity/*COMPLICATIONS/*PSYCHOLOGY  Male  Neurologic Examination
       Neuropsychological Tests  Substance Abuse, Intravenous/*COMPLICATIONS
       JOURNAL ARTICLE

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