Document 0464
 DOCN  M9460464
 TI    Elimination of HIV-infected cells by lymphocytes armed with a
       bifunctional antibody to gp120 of HIV and CD3.
 DT    9404
 AU    Okada H; Momota H; Okada N; Okamoto T; Azuma T; Department of Molecular
       Biology, Nagoya City University School of; Medicine, Japan.
 SO    Immunol Lett. 1993 Nov;38(3):195-9. Unique Identifier : AIDSLINE
       MED/94171285
 AB    The T-cell receptor (TCR) can acquire a new antigen binding site by
       treatment with a bifunctional antibody (BFA) prepared with mAb against a
       specified antigen and an epitope of the TCR. Lymphocytes armed with BFA
       directed to CD3 and an HIV antigen were able to eliminate all HIV
       antigen-positive cells during incubation with a mixture of HIV-infected
       and uninfected cells. HIV antigen-positive cells even from persistently
       infected cells were undetectable with immunofluorescence staining
       although HIV genes were detectable by polymerase chain reaction (PCR)
       amplification indicating that only dormantly infected or low producer
       cells, if any, survived. This suggests that HIV antigen-positive cells
       could be eliminated by administration of BFA-armed lymphocytes leaving
       HIV patients with only dormantly infected or low producer cells.
 DE    Antibodies, Bispecific/IMMUNOLOGY  Antigens, CD3/*IMMUNOLOGY  Cell Line
       Cells, Cultured  Human  HIV Envelope Protein gp120/*IMMUNOLOGY  HIV
       Infections/THERAPY  HIV-1/*IMMUNOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).