Document 0466
 DOCN  M9460466
 TI    Pathogen evolution within host individuals as a primary cause of
       senescence.
 DT    9404
 AU    Bell G; Biology Department, McGill University, Montreal, Quebec, Canada.
 SO    Genetica. 1993;91(1-3):21-34. Unique Identifier : AIDSLINE MED/94171003
 AB    This paper discusses a novel theory of senescence: the community of
       pathogens within each host individual evolves during the life-time of
       the host, and in doing so progressively reduces host vigour. I marshal
       evidence that asymptomatic host individuals maintain persistent
       populations of viral pathogens; that these pathogens replicate; that
       they are often extremely variable; that selection within hosts causes
       the evolution of pathogens better able to exploit the host; that
       selection is host-specific; and that such evolving infections cause
       appreciable and progressive deterioration. Experimental approaches to
       testing the theory are discussed.
 DE    Aging/*PHYSIOLOGY  Animal  *Evolution  Human  HIV/GENETICS  Models,
       Biological  Models, Genetic  Selection (Genetics)  Virus
       Diseases/*MICROBIOLOGY  Virus Replication  Viruses/GENETICS/*PHYSIOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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