Document 0474
 DOCN  M9460474
 TI    Solution structure of HIV-1 protease-allophenylnorstatine derivative
       inhibitor complex obtained from molecular dynamics simulation.
 DT    9404
 AU    Kato R; Takahashi O; Kiso Y; Moriguchi I; Hirono S; School of
       Pharmaceutical Sciences, Kitasato University, Tokyo,; Japan.
 SO    Chem Pharm Bull (Tokyo). 1994 Jan;42(1):176-8. Unique Identifier :
       AIDSLINE MED/94170431
 AB    Structures of two enzyme-inhibitor complexes of human immunodeficiency
       virus-1 protease with allophenylnorstatine derivatives were obtained
       from molecular dynamics simulation in aqueous solution. The stronger
       inhibitor gave considerably smaller fluctuation at P3 site, which formed
       hydrogen bonding with the enzyme flap region.
 DE    Human  HIV Protease Inhibitors/*CHEMISTRY  Isoquinolines/CHEMISTRY
       Models, Chemical  Oligopeptides/CHEMISTRY  Quinolines/CHEMISTRY
       Solutions  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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