Document 0484
 DOCN  M9460484
 TI    Lymphomatous polyarthritis in patients with peripheral T-cell lymphoma.
 DT    9404
 AU    Tachibana J; Shimizu S; Takiguchi T; Ueno Y; Kishimoto I; Wada M; Konda
       S; Department of Internal Medicine, Kanazawa Medical University,;
       Ishikawa, Japan.
 SO    Leuk Lymphoma. 1993 Nov;11(5-6):459-67. Unique Identifier : AIDSLINE
       MED/94169825
 AB    Direct involvement of the joints is a rare complication of malignant
       lymphoma and lymphoma cells in synovium or synovial fluid have been
       characterized in only a very few cases. We report two cases of
       CD4-positive, HTLV-I-negative peripheral T-cell lymphomas that
       manifested polyarthritis infiltrated with lymphoma cells which we
       further characterized. Patient 1, with a prior 7-year history of
       cutaneous T-cell lymphoma (mycosis fungoides) and polyarthralgia,
       developed pain and swelling in the right knee joint and right femoral
       region. Patient 2 was initially diagnosed with immunoblastic
       lymphadenopathy, later rediagnosed as the prodromal stage of T zone
       lymphoma. Seven years later she developed skin eruptions, cervical lymph
       node swelling, polyarthritis, and pleural effusion. Synovial fluid
       analysis in both cases showed predominant CD3+ or cytoplasmic CD3+,
       CD4+, and CD8- atypical lymphoid cell infiltration. In both cases the
       T-cell receptor beta and gamma chains were rearranged in the synovial
       fluid mononuclear cells. Analysis of these two cases and a review of the
       literature suggest that lymphoma cell infiltration of synovium occurs
       preferentially in patients with CD4+ peripheral T-cell lymphoma.
 DE    Adult  Aged  Antigens, CD/ANALYSIS  Arthritis/*ETIOLOGY/PATHOLOGY  Case
       Report  Female  Genotype  Human  HTLV-I/GENETICS  Immunophenotyping
       Lymphoma, T-Cell, Peripheral/*COMPLICATIONS/IMMUNOLOGY/PATHOLOGY
       Synovial Membrane/PATHOLOGY  Virus Integration  JOURNAL ARTICLE

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