Document 0487
 DOCN  M9460487
 TI    Retrospective study of maternal HIV-1 and HIV-2 infections and child
       survival in Abidjan, Cote d'Ivoire.
 DT    9404
 AU    De Cock KM; Zadi F; Adjorlolo G; Diallo MO; Sassan-Morokro M; Ekpini E;
       Sibailly T; Doorly R; Batter V; Brattegaard K; et al; Projet RETRO-CI,
       Abidjan, Cote d'Ivoire.
 SO    BMJ. 1994 Feb 12;308(6926):441-3. Unique Identifier : AIDSLINE
       MED/94169774
 AB    OBJECTIVES--To compare the effects of maternal HIV-1 and HIV-2
       infections on outcome of pregnancy, infant mortality, and child
       survival, and to measure serological concordance between mothers and
       children. DESIGN--Retrospective cohort study with cross sectional study
       of concordance for HIV antibodies. SETTING--Hospital, tuberculosis
       clinic, and maternal and child health centre in Abidjan, Cote d'Ivoire,
       west Africa. SUBJECTS--986 women who had had a total of 2758 pregnancies
       since 1980. The last born children of 194 of these women. MAIN OUTCOME
       MEASURES--Pregnancy outcomes; mortality for all children born since
       1980; and outcome for last born children. Serological concordance
       between mothers and last born children. RESULTS--Women with HIV-1 and
       HIV-2 infections had higher rates of spontaneous abortion and stillbirth
       than uninfected women (86/769 in HIV-1 positive women, 48/421 in HIV-2
       positive, 31/234 in dually reactive, and 96/1131 in uninfected).
       Compared with children born to uninfected mothers (mortality 10.3%),
       greater proportions of children of HIV-1 positive (20.6%) and dually
       reactive (20.3%) mothers had died; mortality in children of HIV-2
       infected women (13.1%) was not significantly increased. Infant
       mortalities for the last born children of HIV-1 positive, dually
       reactive, HIV-2 positive, and seronegative women were, respectively,
       133, 82, 32, and 40 per 1000 live births. Nine of 77 last born children
       of HIV-1 positive mothers were concordantly seropositive compared with
       none of 21 children of HIV-2 infected mothers. CONCLUSIONS--Maternal
       HIV-2 infection has less influence on child survival than infection with
       HIV-1, probably because of a lower vertical transmission rate.
 DE    Age Factors  Child  Child, Preschool  Cohort Studies  Cote
       d'Ivoire/EPIDEMIOLOGY  Female  Human  HIV
       Infections/*EPIDEMIOLOGY/MORTALITY  *HIV-1  *HIV-2  Infant  Infant
       Mortality  Pregnancy  Pregnancy Complications,
       Infectious/*EPIDEMIOLOGY/MORTALITY  Pregnancy Outcome  Retrospective
       Studies  Survival Rate  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).