Document 0499
 DOCN  M9460499
 TI    Probable pentamidine-induced acute pancreatitis.
 DT    9404
 AU    Sauleda J; Gea JG; Aguar MC; Aran X; Pasto M; Broquetas JM; Servei de
       Pneumologia, Hospital del Mar, Universitat Autonoma de; Barcelona,
       Catalonia, Spain.
 SO    Ann Pharmacother. 1994 Jan;28(1):52-3. Unique Identifier : AIDSLINE
       MED/94169497
 AB    OBJECTIVE: To report a case of probable pentamidine-induced acute
       pancreatitis. CASE SUMMARY: A patient was hospitalized because of fever,
       dyspnea, and productive cough. Chest X-ray revealed diffuse alveolar
       infiltrates, and the examination of bronchoalveolar lavage demonstrated
       the presence of Pneumocystis carinii. Intravenous cotrimoxazole was
       administered but the patient's condition did not improve. As secondary
       leukopenia appeared, the treatment was changed to pentamidine
       isethionate 4 mg/kg/d i.v. On day 5 of this new therapy, the patient
       experienced abdominal pain, and both blood and urine amylase
       concentrations raised to 330 U/L and 3960 U/L, respectively. The patient
       died 48 hours later, and signs of acute pancreatitis were observed in
       necropsy. DISCUSSION: With reference to a classical method for
       estimating the probability of adverse drug reactions, a probable
       relationship between pentamidine therapy and acute pancreatitis was
       found in this patient. Furthermore, no alternative causes of
       pancreatitis were present. CONCLUSIONS: It is likely that pentamidine
       administration in our patient resulted in an acute episode of
       pancreatitis. Serum and urine amylase concentrations should be monitored
       in patients receiving this drug.
 DE    Acute Disease  Adult  AIDS-Related Opportunistic Infections/DRUG THERAPY
       Case Report  Human  Male  Methylprednisolone/THERAPEUTIC USE
       Pancreatitis/*CHEMICALLY INDUCED  Pentamidine/*ADVERSE EFFECTS
       Pneumonia, Pneumocystis carinii/DRUG THERAPY
       Trimethoprim-Sulfamethoxazole Combination/THERAPEUTIC USE  JOURNAL
       ARTICLE

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