Document 0502
 DOCN  M9460502
 TI    Human granulocyte colony-stimulating factor (G-CSF), the premier
       granulopoietin: biology, clinical utility, and receptor structure and
       function.
 DT    9404
 AU    Tkatch LS; Tweardy DJ; Department of Medicine, University of Pittsburgh
       School of; Medicine, PA 15213.
 SO    Lymphokine Cytokine Res. 1993 Dec;12(6):477-88. Unique Identifier :
       AIDSLINE MED/94169273
 AB    In summary, both G-CSF and GM-CSF have been identified, cloned, and
       produced for pharmacologic use in humans. While both G-CSF and GM-CSF
       have had significant impact in the treatment of neutropenic states,
       G-CSF appears to be more advantageous than GM-CSF in overall efficacy
       and paucity of side effects. Much has been discovered about the
       structure of the G-CSF receptor but further work is necessary to
       determine its mechanism of signal transduction. As our understanding of
       G-CSF signaling advances, the therapeutic impact of our knowledge about
       G-CSF biology will evolve from the current focus on enhancing its
       effects in hematologic and oncologic illnesses to decreasing its effects
       in inflammatory conditions where overexhuberant neutrophil infiltration
       and activation cause disease.
 DE    Acquired Immunodeficiency Syndrome/THERAPY  Amino Acid Sequence  Animal
       Bone Marrow Transplantation  Granulocyte Colony-Stimulating
       Factor/*PHYSIOLOGY/*THERAPEUTIC  USE  Granulocyte-Macrophage
       Colony-Stimulating Factor/BIOSYNTHESIS
       Granulocytes/METABOLISM/*PHYSIOLOGY  Hematopoiesis/*PHYSIOLOGY  Human
       Leukemia/THERAPY  Molecular Sequence Data  Neoplasms/*THERAPY
       Neutropenia/*THERAPY  Preleukemia/THERAPY  Receptors, Granulocyte
       Colony-Stimulating Factor/BIOSYNTHESIS/  CHEMISTRY/*METABOLISM  Signal
       Transduction  Stem Cells/TRANSPLANTATION  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).