Document 0504
 DOCN  M9460504
 TI    Human T lymphotropic virus type 1 uveitis.
 DT    9404
 AU    Mochizuki M; Tajima K; Watanabe T; Yamaguchi K; Department of
       Ophthalmology, Kurume University School of; Medicine, Fukuoka, Japan.
 SO    Br J Ophthalmol. 1994 Feb;78(2):149-54. Unique Identifier : AIDSLINE
       MED/94169115
 AB    The human retroviruses, HTLV-I and HIV, are playing clinically important
       roles in a variety of ocular disorders, particularly in uveitis. Both
       viruses are integrated in the genome of infected T cells. HIV-I
       infection causes the death of the infected T cells, thereby affecting
       the host defence system and causing AIDS. Subsequent opportunistic
       infections of ocular tissues, such as CMV retinitis, are a serious
       problem in clinical ophthalmology all over the world. Another human
       retrovirus, HTLV-I, has been known as the causative agent of T cell
       malignancies (ATL and T cell lymphoma) and chronic myelopathy (HAM/TSP),
       and is now recognised as a causative agent for a specific type of
       intraocular inflammation characterised by vitreous opacities with mild
       iritis and mild retinal vasculitis (HTLV-I uveitis). The mechanism by
       which HTLV-I causes uveitis is still unknown, but our recent data
       suggest that it is most probably an immune mediated mechanism by
       activated CD4 T cells infected with the virus. HTLV-I uveitis,
       therefore, may implicate a significant role of retroviruses in
       autoimmune diseases and further the pathogenesis of diseases with
       infection/autoimmune overlap.
 DE    Human  HIV Infections/*COMPLICATIONS  HIV Seroprevalence
       *HTLV-I/IMMUNOLOGY  Uveitis/ETIOLOGY/*MICROBIOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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