Document 0514
 DOCN  M9460514
 TI    Cervical and anal neoplasia and HPV infection in persons with HIV
       infection.
 DT    9404
 AU    Northfelt DW; AIDS/Oncology Clinic, University of California, San
       Francisco.
 SO    Oncology (Huntingt). 1994 Jan;8(1):33-7; discussion 38-40. Unique
       Identifier : AIDSLINE MED/94168920
 AB    Prolonged, severe immunodeficiency provides the necessary milieu for the
       emergence of anogenital neoplasia caused by human papillomaviruses.
       Cervical and anal neoplasia are likely to become more common
       manifestations of HIV disease as patients with profound
       immunodeficiency, who would have succumbed to opportunistic infections
       earlier in the epidemic, are now surviving for extended periods of time
       because of increasingly effective antiretroviral, prophylactic, and
       antimicrobial therapies. Cervical cancer in the setting of HIV infection
       appears to be a more aggressive disease, less likely to be successfully
       treated by standard therapies, and consequently associated with a poorer
       prognosis than in comparable non-HIV-infected women. Anecdotal
       observations suggest that anal cancer in HIV-infected persons may share
       these features. Strategies need to be developed for earlier detection
       and treatment of neoplasia and anogenital cancer in the setting of
       HIV-induced immunodeficiency.
 DE    Anus Neoplasms/*COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY/THERAPY  Cervix
       Neoplasms/*COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY/THERAPY  Female  Human
       HIV Infections/*COMPLICATIONS  *Papillomavirus, Human  Papovaviridae
       Infections/*COMPLICATIONS  Tumor Virus Infections/*COMPLICATIONS
       JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

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