Document 0515
 DOCN  M9460515
 TI    Influence of humate on calcium hydroxyapatite implants.
 DT    9404
 AU    Schlickewei W; Riede UN; Yu J; Ziechmann W; Kuner EH; Seubert B;
       Department of Surgery (Traumatology), University Hospital,; Freiburg,
       Germany.
 SO    Arch Orthop Trauma Surg. 1993;112(6):275-9. Unique Identifier : AIDSLINE
       MED/94168851
 AB    Implanted bovine apatite is highly osteoconductive, since it serves the
       host tissue as a guide-line for the deposition of newly developing bone
       tissue. It is well tolerated, but it showed no signs of being resorbed
       during the course of the experiment. Previous impregnation of the bovine
       hydroxyapatite with a low molecular humate substance obviously
       encourages its resorption. This is most easily explained by the known
       ability of humate to induce the activation of leucocytes. The occasional
       over-resorption of the apatite is dependent (1) upon the preparation of
       the implant (granulate) and (2) the local concentration of the humate.
       Future research is being directed towards the production of a
       satisfactorily usable form of humate and apatite and the investigation
       of its HIV blocking action on heterologous cancellous bone.
 DE    Animal  *Biocompatible Materials  Bone and Bones/PATHOLOGY  *Bone
       Transplantation/PATHOLOGY  Cattle  *Durapatite  *Humic Acids  *Implants,
       Artificial  Microscopy, Electron, Scanning  Osseointegration/*PHYSIOLOGY
       Rabbits  JOURNAL ARTICLE

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