Document 0516
 DOCN  M9460516
 TI    Clinical application of gene therapy: emerging opportunities and current
       limitations.
 DT    9404
 AU    McCabe ER; Institute for Molecular Genetics, Baylor College of
       Medicine,; Houston, Texas 77030.
 SO    Biochem Med Metab Biol. 1993 Dec;50(3):241-53. Unique Identifier :
       AIDSLINE MED/94168759
 AB    Protocols for human gene therapy have been approved and a number of
       investigative trials are in place. While somatic gene therapy is favored
       over germline therapy, it must be recognized that transformation of
       somatic cells may occur inadvertently. Ex vivo and in vivo approaches
       offer two different strategies for genetic intervention and are
       discussed in the context of therapy for inborn errors of metabolism,
       brain tumors and other neurological diseases, and AIDS and other
       infectious diseases. Current technology appears quite promising, but
       serious limitations remain before routine application of gene therapy is
       possible.
 DE    Acquired Immunodeficiency Syndrome/THERAPY  Brain Neoplasms/THERAPY
       Central Nervous System Diseases/THERAPY  *Gene Therapy/METHODS/TRENDS
       Human  Metabolism, Inborn Errors/THERAPY  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).