Document 0542
 DOCN  M9460542
 TI    Ultrastructural studies in the lytic phase of progressive multifocal
       leukoencephalopathy in AIDS patients.
 DT    9404
 AU    Boldorini R; Cristina S; Vago L; Tosoni A; Guzzetti S; Costanzi G; V
       Cattedra di Anatomia e Istologia Patologica, Istituto di; Scienze
       Biomediche L. Sacco, Ospedale Sacco, Milano, Italy.
 SO    Ultrastruct Pathol. 1993 Nov-Dec;17(6):599-609. Unique Identifier :
       AIDSLINE MED/94167824
 AB    Brain fragments from eight cases (four autopsies and four biopsies) of
       patients with acquired immune deficiency syndrome (AIDS) with JC virus
       (JCV) lytic infections were examined ultrastructurally. Particular
       efforts were made to look for virions and their subcellular distribution
       in cells not usually involved by papovavirus infection. The cellular and
       subcellular distribution of virions was investigated with emphasis on
       cell types not normally associated with papovavirus infection. The
       pattern of JCV infection was as follows: 1) oligodendrocytes; nucleus
       only, 7 cases; cytoplasm only, no cases; 2) astrocytes (normal and
       bizarre); nucleus and cytoplasm, two cases; cytoplasm only, four cases;
       3) macrophages; nucleus and cytoplasm, one case; cytoplasm only, four
       cases; and 4) neurons; nucleus and cytoplasm, two cases; cytoplasm only,
       three cases. Perivascular, endothelial, ependymal, and microglial cells
       were never infected. Our ultrastructural data indicate that cell types
       other than oligodendrocytes can be involved productively by JCV in the
       lytic phase of progressive multifocal leukoencephalopathy (PML) in AIDS
       patients. Neuronal cells, especially, can be infected productively by
       the JCV, and this should be considered in clinical interpretation of
       cortical symptoms and signs in suspected or proven cases of PML.
 DE    Adult  AIDS-Related Opportunistic Infections/MICROBIOLOGY/*PATHOLOGY
       Brain/*MICROBIOLOGY  Human  Leukoencephalopathy, Progressive
       Multifocal/MICROBIOLOGY/  *PATHOLOGY  Microscopy, Electron  Polyomavirus
       hominis 2/ISOLATION & PURIF/*ULTRASTRUCTURE  Virion/ISOLATION &
       PURIF/ULTRASTRUCTURE  JOURNAL ARTICLE

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