Document 0543
 DOCN  M9460543
 TI    The human immunodeficiency virus integrase protein.
 DT    9404
 AU    Vink C; Plasterk RH; Division of Molecular Biology, The Netherlands
       Cancer Institute,; Amsterdam.
 SO    Trends Genet. 1993 Dec;9(12):433-8. Unique Identifier : AIDSLINE
       MED/94167806
 AB    The DNA integration step in the replication cycle of the human
       immunodeficiency virus (HIV) has been recognized as an important target
       in antiviral strategies. There are two main reasons for this. First,
       integration of HIV DNA into the human genome is required for replication
       of this retrovirus. Second, since the integration reaction does not have
       an obvious cellular counterpart, drugs that specifically inhibit
       integration may not be toxic for the cell. Here, we focus on the only
       protein known to be required for retroviral integration, the integrase
       (IN) protein.
 DE    *DNA Insertion Elements  DNA Nucleotidyltransferases/*METABOLISM
       Support, Non-U.S. Gov't  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).