Document 0552
 DOCN  M9460552
 TI    [Mycobacterium avium intracellulare infections. Treatment with a
       clarithromycin-clofazimine combination. 18 cases]
 DT    9404
 AU    Saint-Marc T; Marneff E; Touraine JL; Service de Transplantation et
       d'Immunologie clinique, Hopital; Edouard Herriot, Lyon.
 SO    Presse Med. 1993 Dec 4;22(38):1903-7. Unique Identifier : AIDSLINE
       MED/94167370
 AB    Infections caused by Mycobacterium avium intracellulare have become
       worrying because of their higher frequency, their new tendency to
       diffuse in all tissues (notably the blood) and the lack of curative
       treatment. The mortality rate remains high and the survival of patients
       after AIDS is diagnosed is estimated at 7.4 months. The effectiveness of
       new antimycobacterial drugs, observed in experiments on beige mice, has
       not yet been confirmed. In 18 patients suffering from this infection,
       either disseminated (88 percent) or localized in the lung (12 percent),
       a 12-week treatment with the clarithromycin-clofazimine combination has
       succeeded in sterilizing the pathological samples. Most patients
       reported a distinct improvement in their general condition, with fall of
       temperature, disappearance of most other symptoms, weight gain and
       better quality of life. Treatment was interrupted in 1 patient owing to
       liver toxicity. In this study the median survival of the patients after
       the Mycobacterium avium complex has been estimated at 11.4 months after
       the diagnosis of AIDS at 28.9 months.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/MORTALITY  Adult
       AIDS-Related Opportunistic Infections/COMPLICATIONS/*DRUG THERAPY/
       MORTALITY  Clarithromycin/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/
       *THERAPEUTIC USE  Clofazimine/ADMINISTRATION & DOSAGE/ADVERSE
       EFFECTS/*THERAPEUTIC  USE  Drug Therapy, Combination  English Abstract
       Hepatitis, Toxic/ETIOLOGY  Human  Male  Middle Age  Mycobacterium
       avium-intracellulare Infection/COMPLICATIONS/*DRUG  THERAPY/MORTALITY
       CLINICAL TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).