Document 0559
 DOCN  M9460559
 TI    Isolated cerebral mucormycosis: case report and therapeutic
       considerations.
 DT    9404
 AU    Gollard R; Rabb C; Larsen R; Chandrasoma P; Department of Medicine,
       University of Southern California Medical; Center-Los Angeles County.
 SO    Neurosurgery. 1994 Jan;34(1):174-7. Unique Identifier : AIDSLINE
       MED/94166957
 AB    Cerebral mucormycosis (without associated involvement of and invasion
       from the nasal sinuses and turbinates) is an extremely rare
       opportunistic infection of the central nervous system. We report the
       case of an intravenous drug abuser (who was negative for the human
       immunodeficiency virus) who presented with hemiparesis on the right
       side, slurred speech, altered mental status, and an unsteady gait.
       Imaging studies revealed a large left-side basal ganglia lesion. A
       stereotactic biopsy obtained a tissue sample that revealed wide,
       nonseptated hyphal fragments with granulomatous inflammation. The
       patient was treated with 3 gm of amphotericin B during a 5-month period.
       The patient had no residual neurological dysfunction after treatment.
       Open surgical resection was not employed. This case suggests that
       stereotactic biopsy followed by long-term amphotericin B therapy, in
       lieu of open surgical resection, represents a viable treatment option
       for this rare disorder.
 DE    Adult  Amphotericin B/ADMINISTRATION & DOSAGE  Basal Ganglia
       Diseases/DIAGNOSIS/PATHOLOGY/*SURGERY  Biopsy, Needle  Brain
       Abscess/DIAGNOSIS/PATHOLOGY/*SURGERY  Case Report  Combined Modality
       Therapy  Human  Male  Mucorales/ULTRASTRUCTURE
       Mucormycosis/DIAGNOSIS/PATHOLOGY/*SURGERY  Neurologic Examination
       Stereotaxic Techniques  JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED
       CASES

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