Document 0582
 DOCN  M9460582
 TI    Cytopathologic and neurochemical correlates of progression to
       motor/cognitive impairment in SIV-infected rhesus monkeys.
 DT    9404
 AU    Rausch DM; Heyes MP; Murray EA; Lendvay J; Sharer LR; Ward JM; Rehm S;
       Nohr D; Weihe E; Eiden LE; Section on Molecular Neuroscience, Laboratory
       of Cell Biology,; National Institute of Mental Health, Bethesda, MD
       20892.
 SO    J Neuropathol Exp Neurol. 1994 Mar;53(2):165-75. Unique Identifier :
       AIDSLINE MED/94165669
 AB    Neurochemical, pathologic, virologic, and histochemical correlates of
       simian immunodeficiency virus (SIV)-associated central nervous system
       (CNS) dysfunction were assessed serially or at necropsy in rhesus
       monkeys that exhibited motor and cognitive deficits after SIV infection.
       Some infected monkeys presented with signs of acquired immunodeficiency
       disease (AIDS) at the time of sacrifice. Seven of eight animals
       exhibited motor skill impairment which was associated with elevated
       quinolinic acid in cerebrospinal fluid (CSF). Examination of the brains
       revealed diffuse increases in glial fibrillary acidic protein
       immunoreactivity in cerebral cortex in all animals, regardless of
       evidence of immunodeficiency disease. Reactive astrogliosis preceded or
       was coincident with the onset of neuropsychological impairments. Virus
       rescue from CSF of six of eight infected animals showed that one of
       three animals with AIDS and none of three animals without AIDS at
       necropsy had virus rescue-positive CSF. Multinucleated giant cells were
       seen in the brain of only one animal with end-stage AIDS and high
       systemic virus burden at death. Neither systemic nor CNS virus burden
       was associated with the onset of CNS dysfunction. SIV-associated
       motor/cognitive impairment is associated with subtle, widespread changes
       in CNS cytology and neurochemistry, rather than with large increases in
       brain virus burden or widespread virus-associated brain lesions.
 DE    Animal  Brain/MICROBIOLOGY/*PATHOLOGY  Cerebral Cortex/PATHOLOGY
       *Cognition  Cognition Disorders/ETIOLOGY  Glial Fibrillary Acidic
       Protein/ANALYSIS  Macaca mulatta  Male  *Motor Activity  Quinolinic
       Acid/BLOOD/CEREBROSPINAL FLUID  Simian Acquired Immunodeficiency
       Syndrome/CEREBROSPINAL FLUID/  *PATHOLOGY/*PHYSIOPATHOLOGY  Spinal
       Cord/MICROBIOLOGY/*PATHOLOGY  Support, Non-U.S. Gov't  SIV/ISOLATION &
       PURIF  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).