Document 0587
 DOCN  M9460587
 TI    Antigen-specific CD8+ T cell clone protects against acute Toxoplasma
       gondii infection in mice.
 DT    9404
 AU    Khan IA; Ely KH; Kasper LH; Department of Microbiology, Dartmouth
       Medical School, Hanover, NH; 03756.
 SO    J Immunol. 1994 Feb 15;152(4):1856-60. Unique Identifier : AIDSLINE
       MED/94165481
 AB    Encephalitis caused by the obligate intracellular protozoan, Toxoplasma
       gondii, is a major cause of morbidity and mortality in those afflicted
       with AIDS. The cell-mediated response is critical for host immunity
       against this parasite. A panel of T cell clones that proliferate in
       response to a major parasite protein, p30 (SAG-1) were isolated from
       mice. One of these clones (C3) bearing the CD8+ phenotype was able to
       induce nearly 100% protection against acute infection when adoptively
       transferred into naive mice. In contrast, an Ag-specific CD4+ T cell
       clone (C2) failed to show significant protection in spite of its ability
       to produce similar quantities of IFN-gamma. Depletion of host CD4+ T
       cells with mAb had no effect on CD8(+)-mediated adoptive protection,
       whereas treatment with anti-IFN-gamma completely abrogated this
       protection. These results indicate that Ag-specific CD8+ T cells in
       combination with IFN-gamma are able to induce significant protection
       against acute toxoplasmosis in the experimental murine model.
 DE    Acute Disease  Animal  Antigens, CD8/*ANALYSIS  Antigens,
       Protozoan/*IMMUNOLOGY  Clone Cells  Cytokines/PHYSIOLOGY  Mice  Mice,
       Inbred BALB C  Protozoan Proteins/*IMMUNOLOGY  Support, U.S. Gov't,
       P.H.S.  T-Lymphocytes/*IMMUNOLOGY  Toxoplasmosis, Animal/*PREVENTION &
       CONTROL  T4 Lymphocytes/PHYSIOLOGY  JOURNAL ARTICLE

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