Document 0594
 DOCN  M9460594
 TI    Detection of subclinical motor dysfunctions in early symptomatic HIV
       infection with topographical EEG.
 DT    9404
 AU    Baldeweg T; Gruzelier JH; Stygall J; Lovett E; Pugh K; Liddiard D;
       Muller J; Riccio M; Hawkins D; Catalan J; Academic Department of
       Psychiatry, Charing Cross & Westminster; Medical School, London, UK.
 SO    Int J Psychophysiol. 1993 Nov;15(3):227-38. Unique Identifier : AIDSLINE
       MED/94164840
 AB    Motor dysfunctions are amongst the earliest and most common signs of
       brain impairment caused by human immunodeficiency virus (HIV) infection.
       Topographical EEG was recorded in patients both with asymptomatic and
       early symptomatic infection (without acquired immunodeficiency syndrome
       (AIDS) defining illness), as well as in seronegative controls under
       resting and motor activation conditions. While patients' motor
       performance did not differ from control values, the EEG showed a
       consistent increase in rhythmic activity in Theta, Alpha and Beta
       frequency bands in Symptomatics. This amplitude increase was evident in
       different topographical regions during resting states as compared with
       motor activation, findings which suggest concurrent involvement of
       several motor areas possibly due to a functional impairment in
       subcortical integratory mechanisms. Comparing motor task and baseline
       both patient groups showed less consistent patterns of task-related EEG
       amplitude reduction than found in the control group. Here topographical
       EEG in connection with motor activation procedures was found to be more
       sensitive than behavioral measures of motor performance and offers a
       technique to assess treatment effects before the development of motor
       abnormalities in patients with HIV infection.
 DE    Adult  *Electroencephalography  Evoked Potentials,
       Somatosensory/PHYSIOLOGY  Eye Movements/PHYSIOLOGY  Fourier Analysis
       Human  HIV Infections/COMPLICATIONS/*PSYCHOLOGY  Male
       Neuropsychological Tests  Psychomotor Disorders/*DIAGNOSIS/ETIOLOGY
       Psychomotor Performance/PHYSIOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

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