Document 0597
 DOCN  M9460597
 TI    Risk of genital human papillomavirus infection in women with human
       immunodeficiency virus-induced immunosuppression.
 DT    9404
 AU    Ho GY; Burk RD; Fleming I; Klein RS; Department of Epidemiology and
       Social Medicine, Montefiore; Medical Center, Bronx, New York.
 SO    Int J Cancer. 1994 Mar 15;56(6):788-92. Unique Identifier : AIDSLINE
       MED/94164732
 AB    This study examined the risk factors for genital human papillomavirus
       (HPV) infection, including HIV-related immunosuppression as well as
       demographic and behavioral factors. Subjects were 207 women with known
       HIV serologic status, the majority of whom were intravenous drug users
       recruited from a methadone treatment program in the Bronx, New York. A
       structured questionnaire interview, cervico-vaginal lavage, and CD4 cell
       measurements were obtained. HPV genomes in the cervico-vaginal cells
       were detected by Southern-blot hybridization. HPV prevalence was 23%
       among HIV seronegatives, 45% among HIV seropositives with CD4 percent >
       20 and 61% among HIV seropositives with CD4 percent < or = 20.
       Multivariate analysis identified the following independent risk factors
       that were significantly associated with HPV positivity: HIV-related
       immunosuppression, < 35 years of age, and never used oral contraceptive
       pills. HIV-related immunosuppression was also associated with a stronger
       Southern-blot signal strength. HIV infection, however, did not increase
       the susceptibility to HPV infection with the oncogenic types (16, 18,
       31, 33 and 35). Women with HIV infection or immunosuppression had a
       higher prevalence of HPV infection with the oncogenic types, but they
       also had an increased prevalence of infection with other HPV types as
       compared to the HIV-seronegative women. The results suggest that
       HIV-related immunosuppression increases the risk of genital HPV
       infection and has an effect on HPV replication.
 DE    Adult  Female  Genital Diseases, Female/IMMUNOLOGY/*MICROBIOLOGY  Human
       HIV Infections/*COMPLICATIONS/IMMUNOLOGY  *Immunocompromised Host
       Multivariate Analysis  *Papillomavirus, Human/IMMUNOLOGY  Papovaviridae
       Infections/*COMPLICATIONS/IMMUNOLOGY  Risk Factors  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  Tumor Virus
       Infections/*COMPLICATIONS/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).