Document 0605
 DOCN  M9460605
 TI    [Lymphocyte subpopulations in bronchoalveolar lavage fluid in AIDS]
 DT    9404
 AU    Hotz P; Loos U; Luderitz B; Medizinische Universitatsklinik Bonn.
 SO    Dtsch Med Wochenschr. 1994 Mar 4;119(9):289-95. Unique Identifier :
       AIDSLINE MED/94163954
 AB    Lymphocyte subpopulations in peripheral blood and bronchoalveolar lavage
       fluid (BAL) were examined in 29 patients with AIDS (26 men, three women;
       median age 32 [16-55] years). Patients in group 1 (n = 12) had no lung
       disease, in group 2 (n = 11) had Pneumocystis carinii pneumonia, in
       group 3 (n = 6) had other lung disease. There were 13 men and two women
       (median age 48 [21-80]) in the control group (bronchoscoped for mild
       pulmonary symptoms: no abnormal findings in the BAL). Compared with the
       control group, patients with AIDS had a significant deficiency in helper
       cells, both in blood (7-23% vs 50%; P < 0.01) as well as in the BAL
       (7-24% vs 52%; P < 0.001). There was a correlation of the percentage
       helper cell proportion in peripheral blood and BAL (for both group 1 and
       2, rs = 0.75; P < 0.05). The proportion of helper cells in peripheral
       blood and BAL in AIDS patients was significantly lower in those with
       than without lung disease (group 1: 23% blood, 24% BAL vs group 2: 9%
       blood, 7% BAL; group 3: 7% blood, 7% BAL; P < 0.02 blood, P < 0.004
       BAL). The percentage proportion of suppressor cells was greater in both
       blood and BAL in AIDS patients (group 1: blood 47%, BAL 63%; group 2:
       blood 44%, BAL 76%; group 3: blood 52%, BAL 75%) than in the controls
       (blood 28%, BAL 33% [P < 0.01], but there was no correlation between
       peripheral blood and BAL. In addition, the absolute number of suppressor
       cells in the lavage (30 cells/microliters in group 1 and 3, 65
       cells/microliters in group 2) was significantly higher than in the
       controls (8 cells/microliters).--In AIDS patients there occurs a
       lymphocytosis in the BAL, while in blood there is a lymphopenia. The
       concordant decrease in helper cells in blood and BAL is decisive for the
       severity of any pulmonary infections.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/  *IMMUNOLOGY
       Adolescence  Adult  Bronchoalveolar Lavage Fluid/*CYTOLOGY  English
       Abstract  Female  Human  Leukocyte Count  *Lymphocyte Subsets
       Lymphocytosis/ETIOLOGY  Lymphopenia/BLOOD/ETIOLOGY  Male  Middle Age
       Neutrophils  Pneumonia, Pneumocystis carinii/COMPLICATIONS/IMMUNOLOGY
       T-Lymphocytes, Helper-Inducer  T-Lymphocytes, Suppressor-Effector
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).