Document 0611
 DOCN  M9460611
 TI    The end of innocence revisited: resistance of herpesviruses to antiviral
       drugs.
 DT    9404
 AU    Field AK; Biron KK; Hybridon, Inc., Worcester, Massachusetts 01605.
 SO    Clin Microbiol Rev. 1994 Jan;7(1):1-13. Unique Identifier : AIDSLINE
       MED/94163588
 AB    In the past 4 years, interest in drug-resistant herpesviruses has
       evolved from the realm of academic laboratory studies to that of great
       clinical importance. Recurrent and persistent infections due to the
       herpes simplex viruses, varicella-zoster virus, and human
       cytomegalovirus have been an unwelcome consequence of immunosuppression
       in graft recipients, cancer patients, and those suffering from AIDS.
       Treatment of these infections with the available antiviral drugs, such
       as acyclovir, ganciclovir, and foscarnet, has resulted in both clinical
       benefit and the emergence of drug-resistant variants. In addition, the
       role of Epstein-Barr virus is being clarified for an array of disease
       syndromes, and therapeutic approaches are beginning to emerge. In the
       present review, the emergence and clinical importance of drug resistance
       among the herpesviruses have been explored. Furthermore, particular
       attention has been focused on our understanding of the mechanisms of
       drug resistance and how that understanding will guide us in the
       development of more effective antiviral drugs and drug usage.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Antiviral
       Agents/PHARMACOLOGY/*THERAPEUTIC USE  Drug Resistance,
       Microbial/GENETICS  Genes, Viral/GENETICS  Herpesviridae/*DRUG
       EFFECTS/GENETICS  Herpesviridae Infections/COMPLICATIONS/*DRUG
       THERAPY/MICROBIOLOGY  Human  Mutation/GENETICS  Support, Non-U.S. Gov't
       Tumor Virus Infections/*DRUG THERAPY/MICROBIOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).