Document 0622
 DOCN  M9460622
 TI    The fastest genome evolution ever described: HIV variation in situ.
 DT    9404
 AU    Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur,
       Paris,; France.
 SO    Curr Opin Genet Dev. 1993 Dec;3(6):878-83. Unique Identifier : AIDSLINE
       MED/94162897
 AB    Human immunodeficiency virus is an RNA virus in which the degree of
       genetic variation observed is phenomenal--up to 20% within an infected
       individual. This is essentially due to remorseless cycles of viral
       replication, most probably due to chronic activation of the immune
       system. It can be estimated that the number of variants in existence
       worldwide must be in excess of 10(14)-10(18), and given the nature of
       RNA viruses even more novel variants should emerge.
 DE    Evolution  *Genome, Viral  Human  HIV/*GENETICS/PHYSIOLOGY  HIV
       Infections/MICROBIOLOGY  Reverse Transcriptase/METABOLISM  Support,
       Non-U.S. Gov't  Time Factors  *Variation (Genetics)  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).