Document 0679
 DOCN  M9460679
 TI    Comparison of bone marrow and hematologic findings in patients with
       human immunodeficiency virus infection and those with myelodysplastic
       syndromes and infectious diseases.
 DT    9404
 AU    Kaloutsi V; Kohlmeyer U; Maschek H; Nafe R; Choritz H; Amor A; Georgii
       A; Pathologisches Institut, Medizinischen Hochschule, Hannover,;
       Germany.
 SO    Am J Clin Pathol. 1994 Feb;101(2):123-9. Unique Identifier : AIDSLINE
       MED/94160938
 AB    The histologic, hematologic, and morphometric findings of 40 patients
       positive for the human immunodeficiency virus (HIV) were compared
       statistically with those of 40 patients with primary myelodysplastic
       syndromes (MDS) and those of 32 HIV-negative patients with infectious
       diseases. The severity of anemia and the abnormalities of erythropoiesis
       in the group of HIV patients were less pronounced than in the group with
       MDS; megakaryopoiesis showed similarities only with the group of
       patients with infectious diseases, and characteristics of dysplasia were
       not observed. Granulopoiesis in MDS showed an increase of blasts in
       several cases; this was not found in any biopsy specimen from the HIV
       group. In addition, a statistically significant increase of
       monocyte-like cells and giant bands could be observed in the bone marrow
       of the HIV patients. The peripheral blood findings and bone marrow
       picture in the series of our HIV patients appeared to be related mainly
       to the influence of opportunistic infections, although a direct effect
       of the HIV itself could not be excluded.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/EPIDEMIOLOGY/PATHOLOGY  Adult
       Aged  Aged, 80 and over  Anemia/BLOOD/PATHOLOGY  AIDS-Related
       Opportunistic Infections/BLOOD/PATHOLOGY  Bone Marrow/*PATHOLOGY
       Communicable Diseases/*BLOOD/EPIDEMIOLOGY/*PATHOLOGY  Comparative Study
       Erythropoiesis/PHYSIOLOGY  Female  Hematopoiesis/PHYSIOLOGY  Human  HIV
       Infections/*BLOOD/EPIDEMIOLOGY/*PATHOLOGY  Male
       Megakaryocytes/PATHOLOGY  Middle Age  Myelodysplastic
       Syndromes/*BLOOD/EPIDEMIOLOGY/*PATHOLOGY  Retrospective Studies
       Severity of Illness Index  JOURNAL ARTICLE

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