Document 0693
 DOCN  M9460693
 TI    Enhancement of EIAV replication and disease by immunization with a
       baculovirus-expressed recombinant envelope surface glycoprotein.
 DT    9404
 AU    Wang SZ; Rushlow KE; Issel CJ; Cook RF; Cook SJ; Raabe ML; Chong YH;
       Costa L; Montelaro RC; Department of Molecular Genetics and
       Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania
       15261.
 SO    Virology. 1994 Feb 15;199(1):247-51. Unique Identifier : AIDSLINE
       MED/94160578
 AB    The potential for antibody-dependent enhancement of replication of
       macrophage/monocyte tropic viruses has posed a significant problem in
       the development of vaccines for several animal and human viruses and has
       raised significant concern in the design of potential AIDS vaccines.
       Using the previously described equine infectious anemia virus/Shetland
       pony system as a model for HIV-1 vaccine development, we have evaluated
       the efficacy of a recombinant subunit vaccine containing a
       baculovirus-expressed envelope surface glycoprotein (gp90) of EIAV. The
       results of these trials demonstrate not only that the recombinant
       vaccine failed to protect against infection by standard homologous and
       heterologous EIAV challenge strains, but that it resulted in a marked
       enhancement of virus replication and exacerbation of disease in
       immunized ponies exposed to the heterologous virus strain. Thus, the
       recombinant EIAV gp90 vaccine provides a novel in vivo model for
       examining in detail the mechanisms of immune enhancement of a lentivirus
       infection and for evaluating strategies to avoid the production of
       deleterious immune responses in AIDS vaccine design.
 DE    Animal  AIDS Vaccines/PHARMACOLOGY  Baculoviridae  Cloning, Molecular
       Equine Infectious Anemia/IMMUNOLOGY/*MICROBIOLOGY/PREVENTION &  CONTROL
       Horses  Human  Infectious Anemia Virus,
       Equine/GENETICS/IMMUNOLOGY/*PHYSIOLOGY  Membrane
       Glycoproteins/GENETICS/IMMUNOLOGY  Recombinant Proteins/*IMMUNOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Vaccines,
       Synthetic/PHARMACOLOGY  Viral Envelope Proteins/GENETICS/*IMMUNOLOGY
       Viral Vaccines/PHARMACOLOGY  Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).