Document 0694
 DOCN  M9460694
 TI    Simian foamy virus type 1 contains a second promoter located at the 3'
       end of the env gene.
 DT    9404
 AU    Mergia A; Department of Comparative and Experimental Pathology, College
       of; Veterinary Medicine, University of Florida, Gainesville; 32610-0145.
 SO    Virology. 1994 Feb 15;199(1):219-22. Unique Identifier : AIDSLINE
       MED/94160572
 AB    Simian foamy virus type 1 (SFV-1) is a member of a distinct subfamily of
       retroviruses that possess a complex genome organization as well as
       complex means of regulating gene expression. This virus encodes a
       transcriptional transactivator (taf) that dramatically increases gene
       expression directed by the viral long terminal repeat. In this report,
       the identification of a second promoter which is significantly
       transactivated by SFV-1 Taf is described. The second promoter is located
       at the 3' end of SFV-1 env gene downstream from position 8158 (1
       represents the first nucleotide sequence of the viral genome). Deletion
       analysis indicated that there are at least two targets for Taf in the
       internal promoter. A time-course analysis of SFV-1 gene expression
       showed that the messages for the regulatory genes were generated prior
       to the transcription of the structural proteins. Therefore, SFV-1
       replication may be regulated by mechanisms that involve a temporal
       pattern of gene expression. The potential role of the internal promoter
       in SFV-1 gene expression and replication is discussed.
 DE    Cell Line  Gene Expression Regulation, Viral  *Genes, env  *Promoter
       Regions (Genetics)  Spumavirus/*GENETICS  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).