Document 0703
 DOCN  M9460703
 TI    [Disseminated nontuberculous mycobacterial infections in AIDS patients]
 DT    9404
 AU    Furrer H; Bodmer T; von Overbeck J; Medizinische Universitatspoliklinik,
       Inselspital Bern.
 SO    Schweiz Med Wochenschr. 1994 Jan 22;124(3):89-96. Unique Identifier :
       AIDSLINE MED/94160109
 AB    Disseminated nontuberculous mycobacteriosis is a frequent and late
       complication of HIV infection. All the 13 patients described here had
       CD4-lymphocyte counts < 20/mm3. The causative agent was mainly M. avium
       complex. But we also found, for the first time, a double infection with
       M. avium complex and M. genavense and one patient with growth of M.
       shimoidei in the blood culture. Clinical signs are nonspecific (fever,
       reduced performance, anemia). Positive cultures of blood or tissue
       biopsies are diagnostic. The therapeutic approach is the combination of
       new macrolides with other antimycobacterial agents. Prognosis is poor,
       mainly due to advanced immunodeficiency, but two of our patients
       survived more than one year after diagnosis. Prophylactic treatment
       should be considered in patients with CD4-counts less than 50/mm3.
 DE    Adult  Antibiotics, Macrolide/THERAPEUTIC USE  AIDS-Related
       Opportunistic Infections/*MICROBIOLOGY  Case Report  English Abstract
       Female  Human  HIV Infections/*COMPLICATIONS  Male  Middle Age
       Mycobacterium avium-intracellulare Infection/COMPLICATIONS/DRUG  THERAPY
       Mycobacterium Infections, Atypical/DRUG THERAPY/*MICROBIOLOGY
       Mycobacterium, Atypical/ISOLATION & PURIF  Prognosis  JOURNAL ARTICLE

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