Document 0734
 DOCN  M9460734
 TI    Resistance to intestinal parasites during murine AIDS: role of alcohol
       and nutrition in immune dysfunction.
 DT    9404
 AU    Watson RR; Department of Family and Community Medicine, University of;
       Arizona, Tucson 85724.
 SO    Parasitology. 1993;107 Suppl:S69-74. Unique Identifier : AIDSLINE
       MED/94159385
 AB    A murine AIDS model with many similarities to human AIDS, LP-BM5 Murine
       Leukaemia, suppresses T and B cell numbers and functions in the
       intestine. This permits chronic colonization by Giardia and
       Cryptosporidium. Cocaine and the nutrient alcohol, which are
       immunosuppressive, further reduce resistance to intestinal parasites and
       intestinal lymphocyte numbers. Protein undernutrition, vitamin E
       supplementation, and alcohol use further modify immune dysfunction
       induced by the murine retrovirus infection. This suggests that both
       undernutrition and nutrient supplementation could affect parasite
       resistance during AIDS. Thus this murine model of human AIDS has great
       potential to accelerate studies of the role of nutrients in immune
       dysfunction and resistance to intestinal parasites.
 DE    Alcohol Drinking/*IMMUNOLOGY  Animal  AIDS-Related Opportunistic
       Infections/*IMMUNOLOGY  Cryptosporidiosis/IMMUNOLOGY
       Cytokines/IMMUNOLOGY  Diet/*ADVERSE EFFECTS  Disease Models, Animal
       Female  Giardiasis/IMMUNOLOGY  Human  Immunity, Natural  Intestinal
       Diseases, Parasitic/*IMMUNOLOGY  Mice  Mice, Inbred C57BL  Murine
       Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).