Document 0762
 DOCN  M9460762
 TI    Multifocal cytomegalovirus demyelinative polyneuropathy associated with
       AIDS.
 DT    9404
 AU    Morgello S; Simpson DM; Department of Pathology, Mount Sinai Medical
       Center, New York, NY; 10029.
 SO    Muscle Nerve. 1994 Feb;17(2):176-82. Unique Identifier : AIDSLINE
       MED/94158933
 AB    A 47-year-old man with acquired immunodeficiency syndrome presented 3
       months antemortem with the onset of lower extremity sensory
       abnormalities. A progressive course of multifocal weakness and sensory
       disturbances ensued. Electrophysiologic studies revealed a generalized
       asymmetric demyelinating polyneuropathy with secondary axonal loss. The
       patient was sequentially treated with plasmapheresis, high dose
       corticosteroids, intravenous immune globulin, and ganciclovir. His
       neuropathy progressed, and he died of a fulminant bronchopneumonia. At
       autopsy the patient had a multifocal cytomegalovirus
       polyradiculoneuropathy, with both demyelinative and necrotizing
       features. While cytomegalovirus may be associated with a variety of
       peripheral nerve syndromes, its clinical presentation as a primary
       demyelinating polyneuropathy is unusual. Its importance vis-a-vis
       potential therapy for AIDS-associated neuropathies is discussed.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Brachial
       Plexus/PATHOLOGY  Brain/PATHOLOGY  Case Report  Cytomegalovirus
       Infections/*COMPLICATIONS/PATHOLOGY  Demyelinating
       Diseases/*ETIOLOGY/PATHOLOGY/PHYSIOPATHOLOGY  Electromyography  Human
       Male  Middle Age  Neural Conduction  Support, U.S. Gov't, P.H.S.  Tibial
       Nerve/PATHOLOGY  JOURNAL ARTICLE

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