Document 0768
 DOCN  M9460768
 TI    Effect of cocaine and murine AIDS on lamina propria T and B cells in
       normal mice.
 DT    9404
 AU    Lopez MC; Watson RR; Department of Family and Community Medicine,
       Arizona Health; Sciences Center, University of Arizona, Tucson 85724.
 SO    Life Sci. 1994;54(9):PL147-51. Unique Identifier : AIDSLINE MED/94158564
 AB    We developed an experimental model to study the effect of daily cocaine
       administration on the mucosal immune system during murine acquired
       immune deficiency syndrome (MAIDS). Mice were infected with LP-BM5
       murine leukemia virus, a retrovirus which causes immunosuppression with
       development of functional murine AIDS. Mice were given cocaine by daily
       intraperitoneal injection for 11 weeks. Our objective was to investigate
       if cocaine treatment could alter the mucosal immune system at the level
       of the intestinal lamina propria (ILP) and if it could further modify
       the already altered mucosal immunity when it was administered to
       MAIDS-mice. Daily cocaine administration induced a significant decrease
       in the number of IgA+ cells with a concomitant increase in the number of
       CD8+ cells per villi in the ILP. Murine retrovirus infection alone
       decreased the number of IgA+ and CD4+ cells in the ILP, and this
       decreased was even more marked when MAIDS mice also received cocaine.
       These data indicate that cocaine administration could potentiate the
       dramatic effect that MAIDS infection has in the mucosal-associated
       lymphoid tissues.
 DE    Animal  Antigens, CD4/IMMUNOLOGY  B-Lymphocytes/*DRUG
       EFFECTS/*IMMUNOLOGY  Cocaine/*TOXICITY  Disease Models, Animal  Female
       IgA/IMMUNOLOGY  Intestinal Mucosa/CYTOLOGY/*DRUG EFFECTS/*IMMUNOLOGY
       Lymphoid Tissue/CYTOLOGY/*DRUG EFFECTS/*IMMUNOLOGY  Mice  Mice, Inbred
       C57BL  Murine Acquired Immunodeficiency Syndrome/*IMMUNOLOGY
       T-Lymphocytes/*DRUG EFFECTS/*IMMUNOLOGY  JOURNAL ARTICLE

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