Document 0784
 DOCN  M9460784
 TI    [Association between diffuse panbronchiolitis and HTLV-I infection]
 DT    9404
 AU    Mukae H; Higashiyama Y; Morikawa T; Kusano S; Morikawa N; Kadota J;
       Kohno S; Hara K; Second Department of Internal Medicine, Nagasaki
       University; School of Medicine, Japan.
 SO    Nippon Kyobu Shikkan Gakkai Zasshi. 1994 Jan;32(1):17-24. Unique
       Identifier : AIDSLINE MED/94158205
 AB    To determine whether HTLV-I infection is associated with diffuse
       panbronchiolitis (DPB), we investigated T-cell surface markers of
       peripheral blood and bronchoalveolar lavage fluid (BALF) in 9 healthy
       volunteers, 6 HTLV-I seronegative DPB patients (HTLV-I(-)DPB) and 8
       HTLV-I seropositive DPB patients (HTLV-I(+)DPB). In peripheral blood, no
       significant difference was observed between HTLV-I(-)DBP and healthy
       volunteers. However, in BALF, HTLV-I(-)DPB showed a significant decrease
       of the CD4/CD8 ratio and an increase of CD8+HLA-DR+ cells compared with
       healthy volunteers. CD3+CD25+ and CD4+HLA-DR+ cells in peripheral blood
       were significantly increased in HTLV-I(+)DPB compared with those in
       HTLV-I(-)DPB. No significant difference was observed in BALF cells
       between HTLV-I(-) and HTLV-I(+)DPB with the exception of CD3+CD25+
       cells. The most striking result was a marked elevation of CD3+CD25+
       cells in 2 of 8 HTLV-I seropositive patients. Microscopic findings of
       open lung biopsy specimens obtained from the 2 patients differed from
       the typical microscopic findings in DPB. From these findings, we
       consider that HTLV-I infection may be associated with pulmonary lesions
       like DPB, but of a different, pathologically distinct, type.
 DE    Adult  Aged  Antigens, Differentiation, T-Lymphocyte/ANALYSIS
       Bronchiolitis/IMMUNOLOGY/*MICROBIOLOGY  Bronchoalveolar Lavage
       Fluid/IMMUNOLOGY  Case Report  English Abstract  Female  Human  *HTLV-I
       Infections/IMMUNOLOGY  Male  Middle Age  JOURNAL ARTICLE

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