Document 0789
 DOCN  M9460789
 TI    Adhesion molecule expression in chronic inflammatory periodontal disease
       tissue.
 DT    9404
 AU    Gemmell E; Walsh LJ; Savage NW; Seymour GJ; Department of Dentistry,
       University of Queensland, Australia.
 SO    J Periodontal Res. 1994 Jan;29(1):46-53. Unique Identifier : AIDSLINE
       MED/94157731
 AB    Differences in lymphocyte populations have been demonstrated in
       gingivitis and periodontitis lesions. A differential expression of
       adhesion molecules may play a role in lymphocyte trafficking in these
       tissues. An indirect avidin biotin immunoperoxidase technique was used
       to stain a range of adhesion molecules in tissue sections of 21 gingival
       biopsies from both gingivitis and periodontitis subjects. These
       specimens were placed into three groups according to the size of the
       infiltrate. ICAM-1, PECAM-1 and LECAM-1 expression on mononuclear cells
       in the inflammatory infiltrates increased significantly with increasing
       size of infiltrate. Approximately 50% of these mononuclear cells were
       LFA-1+ and CD29+. When specimens were grouped according to their
       putative disease status there were no significant differences between
       mononuclear cell adhesion molecule expression in small infiltrates from
       either gingivitis or adult periodontitis subjects. This was also the
       case with larger lesions from both clinical groups. Therefore there does
       not appear to be a differential expression of adhesion molecules on
       lymphocytes in gingivitis and periodontitis tissue. Endothelial cells
       were positive for ICAM-1, PECAM-1, CD29, GMP-140 but negative for
       ELAM-1. Keratinocyte expression of ICAM-1 increased with increasing size
       of infiltrate although in heavy infiltrates, cells in the region of the
       junctional epithelium which were positive in small lesions, became
       ICAM-1 negative. The upper layers of the oral epithelium were positive
       for LECAM-1 in small infiltrates and with increasing size of infiltrate,
       the lower layers and many of the sulcular and junctional epithelium
       keratinocytes were positive.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Antibodies, Monoclonal  Antigens, CD/ANALYSIS  Antigens,
       Differentiation, Myelomonocytic/ANALYSIS  Cell Adhesion
       Molecules/ANALYSIS/*IMMUNOLOGY  Cell Communication  Chronic Disease
       CD4-CD8 Ratio  Endothelium/CYTOLOGY/IMMUNOLOGY  Epithelial
       Attachment/CYTOLOGY/IMMUNOLOGY  Epithelium/CYTOLOGY/IMMUNOLOGY
       Gingivitis/*IMMUNOLOGY  Immunoenzyme Techniques
       Keratinocytes/IMMUNOLOGY  Lymphocyte Function-Associated
       Antigen-1/ANALYSIS  Periodontitis/*IMMUNOLOGY  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).